Single infusions of ketamine have been used successfully to achieve improvement in depressed patients.
Ketamine as a Novel Antidepressant: From Synapse to Behavior
This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry and behavioral levels and describes an integrated model of the action of ketamine in…
Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
A single subanesthetic (intravenous) IV dose of ketamine might have rapid but transient antidepressant effects in patients with treatment-resistant depression (TRD).
Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.
Ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, has shown rapid antidepressant effects, but small study groups and inadequate control conditions in prior studies have precluded a definitive conclusion.
New Hope for Depression
About 30% of all people with depression don’t respond adequately to the available treatments. That’s a dismal failure rate for a class of drugs designed to improve a person’s basic ability to function...
Efficacy of Ketamine in Bipolar Depression: Systematic Review and Meta-analysis
This study suggests that ketamine is effective in treatment-resistant bipolar depression and may reduce suicidal ideation and anhedonia.
The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review
At least 10-20% of the patients suffering from depression meet criteria for treatment-resistant depression (TRD)...
Ketamine therapy treatment of major depressive episodes: a systematic review
Our meta-analysis suggests that single administrations ketamine therapy are efficacious in the rapid treatment of unipolar and bipolar depression.
A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders
Several studies now provide evidence of ketamine hydrochloride's ability to produce rapid and robust antidepressant effects in patients with mood and anxiety disorders that were previously resistant to treatment.
Ketamine in Chronic Pain Management: An Evidence-Based Review
When first and second-line drugs such as opioids, anticonvulsants, or antidepressants fail to provide satisfactory analgesia for the patient with chronic pain, third-line drugs such as ketamine may provide a suitable option...